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KMID : 1237720170500030214
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Anatomy & Cell Biology
2017 Volume.50 No. 3 p.214 ~ p.218
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Expression of glucose transporters in the developing rat skin
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Oh Chang-Seok
Hong Ji-Won
Jin Shun-Nu
Lee Wang-Jae
Lee Young-Soo
Lee Eun-Ju
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Abstract
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We found the changed distribution of glucose transporter (GLUT) proteins in the skin during rat development. At 15 days of gestation, GLUT1 and 2 proteins were expressed in the stratum corneum of epidermal cells. In postnatal skin, however, GLUT1 and 2 exhibit different expression patterns. While GLUT1 expression becomes more restricted to the stratum basale with development, GLUT2 was found mainly in stratum spinosum and granulosum, but not being localized in the stratum basale at any stages of perinatal skin development. Considering all these, it can be speculated that each GLUT protein plays its specific role in different epidermal layers and that the glucose used in mammalian skin in utero could be originated from the amniotic fluid during skin development.
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KEYWORD
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Glucose transporter, Skin, Epidermis, Rat, Immunohistochemistry
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